1．厚积薄发。建立了多能干细胞来源的系列性治疗潜能细胞和组织类器官。例如间充质基质细胞（Circulation 2010）；血管内皮细胞 （Cell Stem Cell 2011）；脊索和髓核细胞（Cell Rep 2020）；视网膜细胞 （Mol Ther. 2020）；肺脏细胞（Clin Infect Dis. 2021）；免疫细胞(Nat Commun  2022)及心肌细胞（Circulation 2022）等，克服了组织细胞来源受限和细胞异质性问题。
2．学以致用。从源头创新到服务于病人，要求可提供高标准的细胞治疗产品。建立了国际PIC/S GMP标准的细胞治疗产品生产中心，为临床研究及治疗应用提供PIC/S GMP级的嵌合抗原受体T细胞 （CD19 CAR-T）及iPSC-MSC产品，推动干细胞和基因治疗技术的转化应用。
3．所获荣誉。2004年美国华人生物科学家协会（SCBA）青年科学家奖;2007年香港大学健康老龄化国际大会青年科学家奖；2012 年国际干细胞研究学会（ISSCR）第10 届 ISSCR 年会旅行奖。

1.Jin L#, Geng L#, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q*, Xu A*. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity.Circulation. 2022 Sep 22  doi 10.1161/CIRCULATIONAHA.122.059631.

2.Zhang Z#, Guo L#, Huang L#, Zhang C, Luo R, Zeng L, Liang H, Li Q, Lu X, Wang X, Ma CY, Shao J, Luo W, Li L, Liu L, Li Z, Zhou X, Zhang X, Liu J, Yang J, Kwan KY, Liu W, Xu Y, Jiang H, Liu H, Du H, Wu Y, Yu G, Chen J, Wu J, Zhang J, Liao C, Chen HJ, Chen Z, Tse HF, Xia H, Lian Q*. Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells. Clin Infect Dis. 2021 Dec 6;73(11):e4154-e4165. doi: 10.1093/cid/ciaa1911.

3.Geng L, Liao B, Jin L, Yu J, Zhao X, Zhao Y, Zhong L, Wang B, Li J, Liu J, Yang JK, Jia W, Lian Q*, Xu A*. β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130. Nat Metab. 2022 May;4(5):608-626. doi: 10.1038/s42255-022-00572-2. 

4.Lian Q*#, Zhang K#, Zhang Z#, Duan F#, Guo L#, Luo W, Mok BW, Thakur A, Ke X, Motallebnejad P, Nicolaescu V, Chen J, Ma CY, Zhou X, Han S, Han T, Zhang W, Tan AY, Zhang T, Wang X, Xu D, Xiang J, Xu A, Liao C, Huang FP, Chen YW, Na J, Randall G, Tse HF, Chen Z, Chen Y, Chen HJ*. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat Commun. 2022 Apr 19;13(1):2028. doi: 10.1038/s41467-022-29731-5.

5.Zhang Z, Yan B, Gao F, Li Q, Meng X, Chen P, Zhou L, Deng W, Li C, Xu W, Han S, Feng H, Li Y, Chen J, Yin Z, Liao C, Tse HF*, Xu A*, Lian Q*. PSCs Reveal PUFA-Provoked Mitochondrial Stress as a Central Node Potentiating RPE Degeneration in Bietti's Crystalline Dystrophy. Mol Ther. 2020 Dec 2;28(12):2642-2661. doi: 10.1016/j.ymthe.2020.07.024

Section B. Selected 5  publications beyond  3 years
1.Li X#, Michaeloudes C#, Zhang Y, Wiegman CH, Adcock IM, Lian Q*, Mak JCW*, Bhavsar PK*, Chung KF. Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways. J Allergy Clin Immunol. 2018 May;141(5):1634-1645.e5. doi: 10.1016/j.jaci.2017.08.017. 

2.Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X, Xu A*. Fibroblast growth factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. Circulation. 2015 May 26;131(21):1861-71. doi: 10.1161/CIRCULATIONAHA.115.015308.

3.Fu QL#, Chow YY#, Sun SJ#, Zeng QX, Li HB, Shi JB, Sun YQ, Wen W, Tse HF, Lian Q*, Xu G*.  Mesenchymal stem  cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic  rhinitis. Allergy 2012 Oct;67(10):1215-22. doi: 10.1111/j.1398-9995.2012.02875.x.

4.Zhang J, Lian Q, Zhu G, Zhou F, Sui L, Tan C, Mutalif RA, Navasankari R, Zhang Y, Tse HF, Stewart CL, Colman A.  A human iPSC model of Hutchinson Gilford Progeria reveals vascular  smooth muscle and mesenchymal stem cell defects. Cell Stem Cell. 2011 Jan 7;8(1):31-45. doi: 10.1016/j.stem.2010.12.002. 

5.Lian Q*, Zhang Y, Zhang J, Zhang HK, Wu X, Zhang Y, Lam FF, Kang S, Xia JC, Lai WH, Au KW, Chow YY, Siu CW, Lee CN, Tse HF*. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation. 2010 Mar 9;121(9):1113-23. doi: 10.1161/CIRCULATIONAHA.109.898312.